pulmonary edema and covid vaccine
2, 26372646. Lian-Hua-Qing-Wen capsules significantly affect virus morphology, inhibit the SARS-CoV-2 replication with the IC50 value of 411.2g/ml, reduce pro-inflammatory cytokines production at the mRNA level, and show anti-inflammatory effect in vitro (Runfeng et al., 2020). When to. Federal government websites often end in .gov or .mil. 157, 104820. doi:10.1016/j.phrs.2020.104820, Yang, X., Yu, Y., Xu, J., Shu, H., Xia, J. a., Liu, H., et al. Traditional Chinese Medicine in the Treatment of Patients Infected with 2019-New Coronavirus (SARS-CoV-2): A Review and Perspective. Extensive studies have been conducted to identify the antiviral and pulmonary edema reducing efficacy of natural compounds, some of which have already been tested specifically against SARS-CoV and SARS-COV-2. PMC It has been reported that transepithelial ion transport in alveolar monolayers can be activated by K+ channel openers in vitro under physiological conditions (Leroy et al., 2006). (2007). Who (2021). Aquaporins in the Lung. Atractylenolide I Inhibits Lipopolysaccharide-Induced Inflammatory Responses via Mitogen-Activated Protein Kinase Pathways in RAW264.7 Cells. 19 (5), 305306. doi:10.1152/ajplung.00376.2005, Li, C., Wang, P., Li, M., Zheng, R., Chen, S., Liu, S., et al. Studies showed that ENaC activators or stimulators can regulate ENaC-dependent fluid absorption in alveolar and pulmonary edema (Fronius, 2013). 346, 16311636. As RAS plays an important role in PFC and AFC, astragaloside IV from Astragalus propinquus is able to protect kidney and respiratory by activating the ACE2-Ang-(17)-Mas pathway in RAS and improving ACE2, Ang-(17), Mas level (Wang et l., 2015; Qu, 2019). It has been shown that the incidence and severity of COVID-19 are closely related to abnormal metabolism of inorganic salts. Immune-modulatory agents for COVID-19 include tocilizumab, human immunoglobulin and the convalescent plasma. Pediatr. Other therapeutic options including organ support, glucocorticoid therapy, nutritional support have been applied to COVID-19 clinical treatment without much knowledge of their efficacy. Pharmacol. Repurposed drugs with proofs of antiviral effects for other viral infections have been tried. Clinical Characteristics of 138 Hospitalized Patients with 2019 Novel Coronavirus-Infected Pneumonia in Wuhan, China. However, palpable lymphadenopathy commonly involving the axilla as an immune response to vaccination may present a clinical diagnostic dilemma especially in persons with . Pulmonary capillary leak syndrome following COVID-19 virus infection J Med Virol. J. Physiology-Lung Cell Mol. J. Cel Physiol 235 (12), 95109523. Viruses 4 (4), 557580. 57 (3), 262265. Sci. Med. Chloroquine and Hydroxychloroquine in Covid-19. Combination Therapy with Cystic Fibrosis Transmembrane Conductance Regulator Modulators Augment the Airway Functional Microanatomy. 383, 23332344. Am. 388 (4), 421436. Pharmacol. (2017). Rev. Med. For patients recovering from COVID-19 who have persistent, progressive, or new respiratory symptoms, we obtain PFTs including spirometry, lung volumes, and diffusion capacity. TABLE 2. 97 (5), 543554. Mohanty SK, Satapathy A, Naidu MM, Mukhopadhyay S, Sharma S, Barton LM, Stroberg E, Duval EJ, Pradhan D, Tzankov A, Parwani AV. Epub 2023 Mar 31. Med. Br. (2020). Transient Receptor Potential (TRP) Channels: a Clinical Perspective. After getting vaccinated for COVID-19, you might experience some temporary symptoms similar to those you might notice when you get a flu shot, such as a sore, swollen arm where you got the shot. Med. Invest. 74 (2), 92101. 11, 1708. doi:10.3389/fimmu.2020.01708, Thanh Le, T., Andreadakis, Z., Kumar, A., Gmez Romn, R., Tollefsen, S., Saville, M., et al. The integrity of PG molecules in the vascular capillary basement membrane can make sure that endothelial permeability to fluid and solutes in a low level. When SARS-COV-2 invades, vascular endothelial cells are damaged, causing insufficient arterial flow and minimal thrombus. The abnormal humoral metabolism and pulmonary edema contribute to the severity of symptoms and fatality of COVID-19 patients. CD44 inhibition reduces the IL-2 induced vascular leakage syndrome, revealing that CD44 may act as a potential target in COVID-19 treatment. 2021 May 7;8:644678. doi: 10.3389/fmed.2021.644678. J. Appl. doi:10.1165/rcmb.2014-0225OC, Yu, Q., Wang, D., Wen, X., Tang, X., Qi, D., He, J., et al. Urgent reconsideration of lung edema as a preventable outcome in COVID-19: inhibition of TRPV4 represents a promising and feasible approach. Pulmonary edema is the disequilibrium between formation and reflux of lung tissue fluid leading to the absorption of massive tissue fluid by lung lymph and vein failure. (2020). 146 (6), 14541455. Sci. Med. A., Hsieh, C.-L., Abiona, O., et al. 64 (15), 20062012. 171 (10), 24742507. The activation of -adrenergic receptor, especially 2 (Mutlu et al., 2004), was found to stimulate Na+ and fluid reabsorption. doi:10.1016/s2213-2600(20)30076-x, Yan, H., Valdes, A. M., Vijay, A., Wang, S., Liang, L., Yang, S., et al. Pulmonary Edema. doi:10.1161/01.RES.0000125623.56442.20, Nayler, W., and Dillon, J. The Add-On Effect of Chinese Herbal Medicine on COVID-19: A Systematic Review and Meta-Analysis. Fatigue, headache, chills, and new or worsened muscle pain were most common. Epub 2020 Jun 29. J. Physiology-Lung Cell Mol. COPD and asthma cause your airways to swell and become blocked with mucus, which can make it hard to breathe. 181 (1), 5361. Cell. doi:10.1152/physrev.1974.54.3.678, Steinritz, D., Stenger, B., Dietrich, A., Gudermann, T., and Popp, T. (2018). (1997). The likelihood of hypertensive patients developing COVID-19, who were treated by ARBs, was reported to decrease by 76% (Yan et al., 2020). Would you like email updates of new search results? Idiopathic pulmonary fibrosis is also a risk factor for severe COVID-19 which can be observed in the CT scans of COVID-19 patients (Xu et al., 2020; George et al., 2020). Biophys. (2020a). J. Biol. 96 (5), 25142519. Biochim. (2020). 157, 104882. doi:10.1016/j.phrs.2020.104882, Zhang, H., and Baker, A. Am. (2019). medRxiv. Several cases of vaccine-induced thrombotic thrombocytopenia from a similar viral vector vaccine (Oxford-AstraZeneca [ChAdOx1 nCoV-19]) have been reported. Amiloride. A Mechanistic Model and Therapeutic Interventions for COVID-19 Involving a RAS-Mediated Bradykinin Storm. COVID-DSNet: A novel deep convolutional neural network for detection of coronavirus (SARS-CoV-2) cases from CT and Chest X-Ray images. Currently, many clinical trials are in progress to test coronavirus treatment, including new drugs and drug repurposing or repositioning. Physiol. Pulmonary Interstitial Pressure and Proteoglycans during Development of Pulmonary Edema. It has been shown that the incidence and severity of COVID-19 are closely related to abnormal metabolism of inorganic salts. Cepharanthine: a Review of the Antiviral Potential of a Japanese-approved Alopecia Drug in COVID-19. Ann. Aldosterone-induced Sgk1 Relieves Dot1a-Af9-Mediated Transcriptional Repression of Epithelial Na+ Channel . J. Clin. There are also several natural compounds which were previously shown to have positive effects on the lung edema-associated targets described in this paper (Zhou et al., 2006; Ho et al., 2007; Ji et al., 2014; Wang et al., 2015; Qu, 2019; Fan et al., 2020; Lung et al., 2020). Meanwhile, the number of patients in the treatment group presenting improved PaO2/FiO2 and ROX index was higher than that of the control group (95.2% vs. 68.4% and 73.7%). Traditional Chinese Medicine for COVID-19 Treatment. CT images of COVID-19 patients revealed fluid and clear liquid jelly in their lungs, both closely linked to HA (Xu et al., 2020; Wang et al., 2020). (2021). (2009). Comment on "Organprotective Effect of Angiotensinconverting Enzyme 2 and its Effect on the Prognosis of COVID19". 23 (5), 289301. The toad venom injection can significantly improve the pulmonary function of COVID-19 patients by regulating PaO2/FiO2 and ROX index and thus alleviate pulmonary edema. (2020). Res. Chem. Med. See this image and copyright information in PMC. Ann. Moreover, lower expression of alveolar Na-K-ATPase promotes pulmonary edema, and when the expression of Na-K-ATPase 1- and 2-subunits decreases, maximal alveolar epithelial fluid clearance is reduced (Looney et al., 2005). Circulation 96 (6), 18471852. Cepharanthine, a bisbenzylisoquinoline alkaloid derived from tubers of Stephania Japonica, was shown to have a wide-spectrum inhibitor of pan--coronavirus (Fan et al., 2020; Rogosnitzky et al., 2020). This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). Fedratinib, an FDA approved JAK2 inhibitor, may be used to reduce the mortality associated with hyperinflammation by suppressing the production of several Th17 cytokines (i.e., IL1b and TNF-alpha, IL21, IL22, IL17) and the formation of pulmonary edema in combination with anti-viral drugs (Yang et al., 2020e). Mechanism of inhibiting ENaC inducing pulmonary edema. N. Engl. J. Physiology-Lung Cell Mol. (2020a). TRPA1 distributes on C-fibers throughout the respiratory system (De Logu et al., 2016). Alternative Names Lung congestion; Lung water; Pulmonary congestion; Heart failure - pulmonary edema Causes Pulmonary edema is often caused by congestive heart failure. Therefore, the S protein determines the host cell of the virus, regulates the viral attachment and fusion with the host cell membrane, and promotes cellular invasion. doi:10.1152/ajplung.00464.2004, Lung, J., Lin, Y. S., Yang, Y. H., Chou, Y. L., Shu, L. H., Cheng, Y. C., et al. Elife 9, e59177. In COVID-19, lung manifestations present as a slowly evolving pneumonia with insidious early onset interstitial pulmonary edema that undergoes acute exacerbation in the late stages and microvascular thrombosis. Salmeterol for the Prevention of High-Altitude Pulmonary Edema. Prc, N. H. C. o. t. (2020). Res. Arek Sarkissian. Human iPSC-Derived Cardiomyocytes Are Susceptible to SARS-CoV-2 Infection. We are grateful to all of the colleagues who have given critical comments on this work. Lab. Care 21 (1), 305. doi:10.1186/s13054-017-1882-z, Zhang, H., Kang, Z., Gong, H., Xu, D., Wang, J., Li, Z., et al. 225 (4), 618627. J. Med. Exp. The structure of coronavirus (Figure 1 A vision of coronavirus with the minimal set of structural proteins.) TRPV4: Physiological Role and Therapeutic Potential in Respiratory Diseases. Decreased Expression of Aquaporin-5 in Bleomycin-Induced Lung Fibrosis in the Mouse fibrosis in the Mouse. J. Cel Mol Med 24 (8), 47364747. Mol. Dexamethasone for the Treatment of Coronavirus Disease (COVID-19): a Review. (2019). Cause of COVID-19 pulmonary edema. Bookshelf Infection, pulmonary edema, lung cancer, aspiration, and pulmonary hemorrhage are some of the diseases that can cause consolidation. The Potential Chemical Structure of antiSARSCoV2 RNAdependent RNA Polymerase. COVID-19 Treatment and Diagnosis Guideline (7th version, trial) [Online]. Pharmacol. doi:10.1016/j.antiviral.2006.04.014, Hofer, C. C., Woods, P. S., and Davis, I. C. (2015). Science 367 (6483), 12601263. Presenting Characteristics, Comorbidities, and Outcomes Among 5700 Patients Hospitalized with COVID-19 in the New York City Area. 33, 258269. 12:664349. doi: 10.3389/fphar.2021.664349. Inhibition of ACE2 by SARS-CoV-2 impairs the hydrolysis of des-arg9-bradykinin. Clin. doi:10.1016/j.jinf.2020.02.017, Xu, Z., Shi, L., Wang, Y., Zhang, J., Huang, L., Zhang, C., et al. Moreover, the peripheral blood mononuclear lymphocyte of COVID-19 patients was also greatly improved, from 0.91 0.54 to 1.24 0.67 after being treated for a week, while there was no obvious change in control group (Hu et al., 2020). The Liu Shen capsule, of which pharmacodynamic component is also toad venom, was shown to have antiviral and anti-inflammatory activity against SARS-CoV-2 in vitro, as it can inhibit the replication of SARS-CoV-2 in Vero E6 cells, reduce inflammatory cytokines production at the mRNA levels and suppress the NF-B signaling pathway to downregulate the expression of cytokines (Ma et al., 2020a).
