does ashwagandha interact with medications

Its botanical name is Withania somnifera and it is also known as "Indian ginseng . 2016;5(4):40. doi:10.3390/antiox5040040, Vitale KC, Hueglin S, Broad E. Tart cherry juice in athletes: a literature review and commentary. It is mandatory to get consent from the doctor before taking it. People who are pregnant or breastfeeding should not use ashwagandha. Overall, ashwagandha doesn't seem to have many reported significant drug interactions. Effect of an ashwagandha (Withania Somnifera) root extract on climacteric symptoms in women during perimenopause: A randomized, double-blind, placebo-controlled study. What about black My Dr. put me on 500mg of cephalexin 3 times a day and 150mg of fluconazole. 1993;31(7):607-611. Efficacy of Withania somnifera supplementation on adult's cognition and mood. Effects of ashwagandha (Withania somnifera) on physical performance: systematic review and Bayesian meta-analysis. Thank you, {{form.email}}, for signing up. Evid Based Complement Alternat Med. It's best to talk to your doctor before you start taking antidepressants and vitamins, especially mixed supplements. Ashwagandha interacts with several types of prescription medicine, so consult your health care provider before taking this herbal remedy. Herbal supplements can strongly affect the body. Examples of immunosuppressants include azathioprine, cyclosporine, mycophenolate, prednisone and corticosteroids. Hidese S, Ogawa S, Ota M, et al. Ashwagandha interferes with immunoassay measurements of digoxin, a medication primarily used for treating congestive heart failure and abnormal heart rhythms. Do not use this product if you are pregnant or plan to become pregnant soon. CONDITIONS OF USE AND IMPORTANT INFORMATION: This information is meant to supplement, not replace advice from your doctor or healthcare provider and is not meant to cover all possible uses, precautions, interactions or adverse effects. View abstract. 2012;10(1):48-49. levothyroxine, desiccated thyroid) could potentially increase thyroid hormone levels too much, increasing the risk of side effects. Vitamin D supplementation improves anxiety but not depression symptoms in patients with vitamin D deficiency. Safety of ashwagandha root extract: a randomized, placebo-controlled, study in healthy volunteers. It's worth noting that a drawback of both these studies is that they were performed on small sample sizes. Khattak, S., Saeed, Ur Rehman, Shah, H. U., Khan, T., and Ahmad, M. In vitro enzyme inhibition activities of crude ethanolic extracts derived from medicinal plants of Pakistan. No, Ashwagandha does not possess any qualities that cause it to be habit forming, and the risk of forming an addiction to Ashwagandha is little to none. A randomized double blind placebo controlled study of ashwagandha on generalized anxiety disorder. Altern Med Rev 2000;5:334-46. The herb has been proven to interact with many other drugs, the interaction with SSRI (selective serotonin reuptake inhibitor) or Benzodiazepines are not proven scientifically. Biogerontology. Malhotra, C. L., Mehta, V. L., Das, P. K., and Dhalla, N. S. Studies on Withania-ashwagandha, Kaul. 2020. Withania somnifera extract. One study, published in Phytotherapy Research, reported that ashwagandha supplementation reduced blood sugar and A1c levels, although this was a relatively small study. According to the NIH, ashwagandha may interact with certain prescription medications, including antidiabetes drugs, antihypertensive drugs, immunosuppressants, benzodiazepines, certain sedative . Kumar S, Bouic PJ, Rosenkranz B. . Diarrhea. The exact type of antidepressant you're taking will determine which foods, vitamins and supplements you should or should not ingest. Use WebMD's Drug Interaction Checker tool to find and identify potentially harmful and unsafe combinations of prescription medications by entering two or more drugs in question. Ashwaganda is used to treat Herbal Supplementation. Gopal S, Ajgaonkar A, Kanchi P, et al. A double-blind, randomized, placebo-controlled trial on the effect of Ashwagandha (Withania somnifera dunal.) ashwaganda ashwagandha (Withania somnifera) Entire Monograph Reported Uses Reported Doses Cautions Drug Interactions Adverse Reactions Synonyms Other Info Add to Interaction Check Complement Ther Med. Can You Take A Z-Pak If You Have A Penicillin Allergy? low blood sugar). Influence of an Indian medicine (Ashwagandha) on acute-phase reactants in inflammation. Dasgupta A, Peterson A, Wells A, Actor JK. In rare cases, the use of ashwagandha may lead to liver damage. 2011;68(1):3-8. Varying levels of research have looked at the potential benefits of ashwagandha. Anbalagan, K. and Sadique, J. Feel free to send him an email at Hello@HelloPharmacist.com! Sud Khyati S, Thaker B. Underactive Thyroid. 2020;40(4):825-829. View abstract. J Med Food 2022. According to the Cleveland Clinic, there are six different types of medications commonly used to treat depression. J Diet Suppl. Again, be sure to talk to your doctor about adding ashwagandha to immunosuppressant drugs. Ghosal S, Lal J, Srivastava R, and et al. Panda S, Kar A. Withania somnifera and Bauhinia purpurea in the regulation of circulating thyroid hormone concentrations in female mice. Many of the studies on ashwagandha have been performed in laboratory settings or on animal models, but some human trials do exist. View abstract. Aerobic capacity and recovery were assessed for all participants throughout the study. Deocaris, C. C., Widodo, N., Wadhwa, R., and Kaul, S. C. Merger of ayurveda and tissue culture-based functional genomics: inspirations from systems biology. Ashwagandha - More Interactions. . Thyroid Suppression Test. As always, be sure to talk to your doctor about combining any over-the-counter dietary supplement with your prescribed drugs as they have your complete medical profile. Taking ashwagandha along with these medications might decrease the effects of these medications. Efficacy and safety evaluation of ayurvedic treatment (ashwagandha powder and sidh makardhwaj) in rheumatoid arthritis patients: a pilot perspective study. Kulkarni, S. K. and Dhir, A. Withania somnifera: an Indian ginseng. View abstract. . If you take thyroid medicine, consult your doctor before using ashwagandha. Immunopharmacol.Immunotoxicol. Remenapp A, Coyle K, Orange T, et al. An eight-week safety study found that taking 300 milligrams daily of ashwagandha was safe for both males and females. J Ethnopharmacol. Do note that ashwagandha itself does not . For more information on drug interactions, visit the RxList Drug Interaction Checker. 2021;18(2):183-226. doi:10.1080/19390211.2020.1741484, D'Cruz M, Andrade C. Potential clinical applications of Ashwagandha (Withania somnifera) in medicine and neuropsychiatry. Sharada, A. C., Solomon, F. E., Devi, P. U., Udupa, N., and Srinivasan, K. K. Antitumor and radiosensitizing effects of withaferin A on mouse Ehrlich ascites carcinoma in vivo. Read our. It is commonly used for stress. Are there any side effects of ashwagandha? Myxedema Coma. J Ethnopharmacol. It is also recommended that people with hormone-sensitive prostate cancer avoid using ashwagandha due to possible hormone changes caused by the herb. J Ayurveda Integr Med. However, scientific evidence supporting these and other uses is poor. When possible, choose a supplement tested by a trusted third party, such as U.S. Pharmacopeia (USP), ConsumerLab, or NSF. glipizide, glyburide, glimepride), SGLT2 Inhibitors (e.g. Some of these sedative medications include clonazepam (Klonopin), diazepam (Valium), lorazepam (Ativan), and others. Other essential vitamins and minerals may also be helpful in treating depression. Medically reviewed by Drugs.com. Twelve studies were included in the final review, and researchers concluded that ashwagandha showed more improvements in physical performance than placebo pills. Am J Drug Alcohol Abuse 2009;35(1):1-11. Moderate 623 Interactions; Unknown 2123 Interactions; Interaction Rating Key. 2013;74(11):1076-83. Herbal supplements, like St. John's wort or garcinia cambogia, are much more likely to affect the functionality of your antidepressants compared to vitamins or mineral tablets. Ashwagandha contains several active constituents including: The mechanism of how ashwagandha works, for all of its purported benefits, is not well understood. Is It Safe To Take Keflex (Cephalexin) With Birth Control? Mishra LC, Singh BB, Dagenais S. Scientific basis for the therapeutic use of Withania somnifera (ashwagandha): a review. View abstract. You can also connect with Dr. Brian Staiger on LinkedIn. Effect of a medicinal plant (Passiflora incarnataL) on sleep. Int Ayurvedic Med J 2013;1(5):1-7. J.Altern.Complement Med. Ashwagandha side effects. Ultimately, the supplements and foods you can . Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances. metoprolol, nebivolol, propranolol), Diuretics (e.g. Holistic Medicine 42 years experience. Withania somnifera improves semen quality by regulating reproductive hormone levels and oxidative stress in seminal plasma of infertile males. Malhotra, C. L., Mehta, V. L., Prasad, K., and Das, P. K. Studies on Withania ashwagandha, Kaul. J Diet Suppl. Because ashwagandha supports immune system function, it might interact with medications designed to reduce immune system activity, known as immunosuppressants, according to the University of Maryland Medical Center. Yes: Ashwagandha is a wonderful tonic that reduces inflammation, balances hormones and supports immune function. View abstract. Ashwagandha has mild interactions with at least 29 different drugs. Taking ashwagandha with thyroid hormone pills might cause too much thyroid hormone in the body, and increase the effects and side effects of thyroid hormone. Change in balance, feeling shaky, or unsteady, Not able to think clearly or change in thinking, US Department of Defense Dietary Supplement Resource, https://www.opss.org/article/ashwagandha-dietary-supplement-products, This generalized information is a limited summary of diagnosis, treatment, and/or medication information. J Ethnopharmacol 1991;33:91-5. However, there is concern that herbs like ashwagandha may have interactions that have . Ashwagandha is thought to have a positive impact on chronic stress. 2020;40(4):825-829. doi:10.1111/liv.14393, Siddiqui S, Ahmed N, Goswami M, Chakrabarty A, Chowdhury G. DNA damage by withanone as a potential cause of liver toxicity observed for herbal products ofWithania somnifera(ashwagandha). Cancer Lett. View abstract. View abstract. Brain Behav. Deshpande A, Irani N, Balkrishnan R, Benny IR. You will need to talk about the benefits and risks of using this natural product. View abstract. Never delay or disregard seeking professional medical advice from your doctor or other qualified health care provider because of something you have read on WebMD. Doses higher than that may interact with lexapro, or produce more pronounced effects. You should always speak with your doctor or health care professional before you start, stop, or change any prescribed part of your health care plan or treatment and to determine what course of therapy is right for you. Ireland PJ, Hardy T, Burt AD, Donnelly MC. This is called a medicine interaction. Ashwagandha-induced liver injury: A case series from Iceland and the US Drug-Induced Liver Injury Network. The combination could decrease the effectiveness of these medications. For this reason, it's always best to tell a healthcare provider if you are taking any medications and/or supplements before starting a new supplement. 2013;45(4):417-8. View abstract. 2003;19(3):211-222. Bull Natl Res Cent. 2018 Mar;24(3):243-248. These include drugs like thyroid desiccated, levothyroxine, or liotrix. Last updated Apr 30, 2023 Key points Ashwagandha has not been well studied in regard to potential interactions with prescription medication. A total of 0 drugs are known to interact with ashwaganda. Another traditional use of ashwagandha in Ayurveda is for memory issues. Lopresti AL, Smith SJ, Malvi H, Kodgule R. An investigation into the stress-relieving and pharmacological actions of an ashwagandha (Withania somnifera) extract: A randomized, double-blind, placebo-controlled study. If you're interested in taking a nutritional supplement to support your treatment for depression, talk to your doctor so you can find the one that works best for you and doesn't affect your antidepressants. I was told that I had an allergic reaction to penicillin when I was a child. 2008;9(6):369-374. After 30 days, those who took either dose of ashwagandha self-reported positive effects on their anxiety. Essential vitamins, minerals and amino acids that are involved in neurobiological function include: However, several of these have had mixed results in helping support depression treatment. Herbs like Ashwagandha are known to interact with SSRI and other medicines. J Ayurveda Integr Med. Ashwagandha might cause sleepiness and drowsiness. National Center for Complementary and Integrative Health. View abstract. Lousewort - Amiloride, Hydrochlorothiazide, Cassia Cinnamon - Aspirin, Butalbital, Caffeine, Abuta - Bismuth Subcarbonate, Calcium Carbonate, Opium, English Adder's Tongue - Inotuzumab Ozogamicin, Patricia Kane (pk) Protocol - Indomethacin, Pulsed Electromagnetic Field (pemf) Therapy - Cabozantinib. Harvard Health Publishing states that other medications, supplements and your diet all have the potential to affect the way your body processes your antidepressants. Hypothyroidism, After Thyroid Removal. Therefore, before using this product, tell your doctor or pharmacist of all the . This includes: As with many other herbs and supplements, ashwagandha has a risk of side effects. We comply with the HONcode standard for trustworthy health information. To prolong shelf life, ashwagandha supplements should be stored in a cool, dry place. Per the research, ashwagandha demonstrated small but significant benefits on overall sleep for those with insomnia. Dhuley, J. N. Therapeutic efficacy of Ashwagandha against experimental aspergillosis in mice. Prez-Gmez J, Villafaina S, Adsuar JC, Merellano-Navarro E, Collado-Mateo D. Effects of ashwagandha (Withania somnifera) on VO2max: A systematic review and meta-analysis. Fortunately, no cases resulted in liver failure, and all recovered. Ashwagandha might lower blood pressure. Levothyroxine is in the drug class thyroid drugs . Phytotherapy Research 1989;3(5):201-206. Cureus. Last updated on Feb 3, 2023. Kumar G, Srivastava A, Sharma SK, Rao TD, Gupta YK. This can result in serotonin syndrome, which causes side effects like anxiety, sweating, confusion, tremors, lack of coordination and an accelerated heart rate. Tharakan A, Shukla H, Benny IR, Tharakan M, George L, Koshy S. Immunomodulatory Effect of Withania somnifera (Ashwagandha) Extract-A Randomized, Double-Blind, Placebo Controlled Trial with an Open Label Extension on Healthy Participants. Sometimes, these supplements are stand-alone products or multivitamins; in other cases, they are mixed in with healthy food products, like spirulina, chlorella or herbal products. Pharmacol Biochem.Behav 2003;75(3):547-555. There is little evidence for its use as an "adaptogen." Ashwagandha contains chemicals that might help calm the brain, reduce swelling, lower blood pressure, and alter the immune system. J Ethnopharmacol 1999;64:91-3. 2020;34(5):1041-1059. People with thyroid conditions or who are taking thyroid medications should talk with a healthcare provider before using ashwagandha. Some symptoms of high thyroid hormone levels include fatigue, increased appetite, sweating, restlessness, diarrhea, hair loss, insomnia, itching and high blood pressure. 4. Ashwagandha, an herbal supplement commonly used in traditional Indian medicine, is the latest fad herb trending on social media. Headache. A variety of of vitamins and nutritional supplements have been shown to help treat depression. View abstract. Xanax is used to treat the following conditions: Anxiety; Panic Disorder; Drug and food interactions Andallu B, Radhika B. Hypoglycemic, diuretic and hypocholesterolemic effect of winter cherry (Withania somnifera, Dunal) root. 1985;23(4):177-183. 8 Warning Signs of Depression You Shouldn't Ignore, Depression in Adults With a Chronic Physical Health Problem: Treatment and Management, How Vegans Can Get All Their Nutrients (Without Taking Supplements), Complementary Therapies in Medicine Journal, 15 Celebrities Who Struggle With Anxiety and Depression, Australian Journal of Herbal Medicine: "B Vitamins Enhance Antidepressant Response in Adults", Open Neurology Journal: "Vitamin B12 Supplementation in Treating Major Depressive Disorder: A Randomized Controlled Trial", Journal of Psychiatry: "Adjunctive Nutraceuticals for Depression: A Systematic Review and Meta-Analyses", Mayo Clinic: "MAOIs and Diet: Is It Necessary to Restrict Tyramine? Bhat, J., Damle, A., Vaishnav, P. P., Albers, R., Joshi, M., and Banerjee, G. In vivo enhancement of natural killer cell activity through tea fortified with Ayurvedic herbs. Although, it's important to note that long-term studies have not been performed on ashwagandha. Indian J Exp Biol 1997;35:236-9. A recent study out of India compared varying doses of ashwagandha to a placebo for the treatment of stress. View abstract. J Obstet Gynaecol Res 2021. Cureus. PLoS One 2009;4:e6628. According to one study that examined ashwagandha's effect on athletics, ashwagandha may improve both endurance and recovery in healthy adult athletes. However, there is concern that herbs like ashwagandha may have interactions that have not yet been identified. This copyrighted material is provided by Natural Medicines Comprehensive Database Consumer Version. Ashwagandha may be able to help with insomnia. 2013;2013:571420. drugs for diabetes and blood pressure). Ashwagandha may interact with various medications. Nagashayana N, Sankarankutty P, Nampoothiri MRV, et al. In the study, no adverse events were reported by participants who took the herb. The liver damage never progressed to liver failure, and most cases were resolved within five months. View abstract. J.Transl.Med. Per the review, five people experienced liver toxicity after taking varying brands and doses of ashwagandha for different lengths of time. The roots can be used topically as a poult. Some vitamins and supplements can interfere with blood-thinning blood pressure drugs, Dr. Glatter says. A 2020 case study examined five adults who had experienced signs of hepatotoxicity, or toxicity to the liver, after using ashwagandha in varying doses. Avoid beer, wine, and mixed drinks (alcohol) while taking this product. Indian J Physiol Pharmacol. J Neurol Sci 2000;176:124-7. However, you should not stop taking any prescribed medication. It is not intended to be medical advice or a substitute for the medical advice, diagnosis, or treatment of a health care provider based on the health care provider's examination and assessment of a patients specific and unique circumstances. Hello! Does Ashwagandha supplementation have a beneficial effect on the management of anxiety and stress? Dhuley, J. N. Effect of ashwagandha on lipid peroxidation in stress-induced animals. View abstract. Some of these interactions can be life-threatening. View abstract. 1998;60(2):173-178. However, if you were to combine St. John's wort with antidepressants like SSRIs, you could end up with disastrous results. This herb used in alternative medicine may help reduce stress. Some barbiturates include phenobarbital, pentobarbital and secobarbital. Withania somnifera, known as ashwagandha, has a role in ayurvedic medicine for a wide range of health conditions. View abstract. ashwagandha and guggul used for thyroid conditions and find out if they are beneficial. Ashwagandha has no known moderate interactions with any drugs. Take extra care and check with your doctor if you have: Signs of a very bad reaction. This article provides a review of the potential uses of ashwagandha. Complement Ther Med 2016 Aug;27:25-9.View abstract. View abstract. When taken inappropriately, ashwagandha can have side effects and potentially serious medicinal interactions. Certain ingredients can influence the effectiveness of your antidepressants and how they affect your health. From the study results, researchers concluded that ashwagandha improved memory and focus. View abstract. Panda S, Kar A. Mandlik Ingawale DS, Namdeo AG. J Ethnopharmacol 1999;67:27-35. It may cause you to become sleepy or drowsy. From retail, clinical, program development, and administrative responsibilities, he's your knowledgeable and go-to source for all your pharmacy and medication-related questions! However, the review noted various limitations of the studies, including study design and potential bias. TSH Suppression. Am J Ther 2023;30(1):e80-e83. doi:10.7759/cureus.6466, Lopresti AL, Smith SJ, Malvi H, Kodgule R. An investigation into the stress-relieving and pharmacological actions of an ashwagandha (Withania somnifera) extract: a randomized, double-blind, placebo-controlled study. These are drugs like diazepam, lorazepam, phenobarbital, or zolpidem. Due to an overall lack of scientific evidence, there are no standard dosage guidelines for ashwagandha. Ashwagandha might increase how much thyroid hormone the body produces. Also learn why ingredients such as alpha-lipoic acid, soy, resveratrol, quercetin may impair thyroid function. Praveenkumar, V., Kuttan, R., and Kuttan, G. Chemoprotective action of Rasayanas against cyclosphamide toxicity. Researchers of the study believed that these results were due to the ability of ashwagandha to moderate the body's stress response. Some products may not mix well with other drugs or natural products. This product may cause you to be sleepy. A total of 525 drugs are known to interact with Xanax. Biochem.Biophys.Res Commun. Fertil Steril 2010;94:989-96. Agarwal R, Diwanay S, Patki P, Patwardhan B. Some of the more compelling potential uses of ashwagandha are outlined below. Herb-drug interactions. View abstract. Supplements That Are Similar to Ashwagandha. 2021;51(4):363-365. IV. In rare cases, ashwagandha may cause liver damage. Additionally, a pilot study looked at ashwagandha's effects on people with mild cognitive impairment. In recent years, some researchers have assessed how ashwagandha may benefit physical performance. Cooley K, Szczurko O, Perri D, et al. Devi, P. U., Sharada, A. C., and Solomon, F. E. Antitumor and radiosensitizing effects of Withania somnifera (Ashwagandha) on a transplantable mouse tumor, Sarcoma-180. Taking high doses of ashwagandha may increase your risk of side effects. Long term effect of herbal drug Withania somnifera on adjuvant induced arthritis in rats. Bhattacharya, S. K., Bhattacharya, A., Sairam, K., and Ghosal, S. Anxiolytic-antidepressant activity of Withania somnifera glycowithanolides: an experimental study. Effect of Withania somnifera (Ashwagandha) on the development of chemotherapy-induced fatigue and quality of life in breast cancer patients. Investigation of CYP2B6, 3A4 and -esterase interactions of Withania somnifera (L.) dunal in human liver microsomes and HepG2 cells. By Brittany Lubeck, RD The most common side effects include: Other less common side effects of ashwagandha include: If you experience side effects when taking ashwagandha, be sure to stop using it and seek advice from a healthcare provider. of signs you need emergency medical attention or call 911. I am wondering if it is okay to take with my prescriptions. Additionally, ashwagandha may increase testosterone levels in the body. It's much more likely for certain foods, like grapefruit juice or herbal supplements, to affect antidepressant function. View abstract. 2017;10(3):96-100. doi:10.5935/1984-0063.20170018. In our latest question and answer, the pharmacist discusses whether or not ashwagandha supplements interact with prescription drugs. Some medications, such as those used after a transplant, decrease the activity of the immune system. Take extra care if you are taking drugs to help with your thyroid. Taking ashwagandha with sedative medications might cause breathing problems and/or too much sleepiness. Ahumada F, Aspee F, Wikman G, Hancke J. Withania somnifera exract. It is just a general precaution that ashwagandha may decrease blood sugar. You may think that these supplements are safe because they also have antidepressant effects, but it's not that simple. We can, however, make some educated guesses on drug interactions based on ashwagandha works, and the effects it is known to have.

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